Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901375 | 0.84 | MEN1 (0.60) | MEN1KMT2ADYRK1AADORA2AADORA1 | |
| SCHEMBL4546868 | 0.84 | ADORA2A (0.53) | MEN1KMT2AADORA2AADORA1ADORA2B | |
| SCHEMBL27430949 | 0.82 | ADORA2A (0.52) | MEN1KMT2AADORA2AADORA1ADORA2B | |
| SCHEMBL9218143 | 0.78 | MEN1 (0.50) | MEN1KMT2AADORA2AADORA1ADORA2B | |
| SCHEMBL13933596 | 0.78 | ADORA2A (0.66) | MEN1KMT2AADORA2AADORA1ADORA2B | |
| SCHEMBL316979 | 0.77 | MEN1 (0.58) | MEN1KMT2AADORA2AADORA1ADORA2B | |
| SCHEMBL4257749 | 0.77 | MEN1 (0.79) | MEN1KMT2AADORA2AADORA1ADORA2B | |
| SCHEMBL3185376 | 0.76 | MEN1 (1.00) | MEN1KMT2AADORA2AADORA1KDM4E | |
| SCHEMBL23860768 | 0.75 | KDM4E (0.53) | MEN1KMT2ADYRK1AADORA2AADORA1 | |
| SCHEMBL19417164 | 0.75 | MEN1 (0.83) | MEN1KMT2AADORA2AADORA1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | PFKFB3, PFKFB4, PFKFB1 | MEN1 3253/4885KMT2A 1147/4885DYRK1A 2727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.