Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MYB | P10242 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14381008 | 0.79 | ENPP3 (0.35) | PIM1 | |
| SCHEMBL4828459 | 0.79 | ADORA2A (0.38) | PIM1ALOX15ADORA2A | |
| SCHEMBL4835226 | 0.78 | ENPP1 (0.50) | ALOX15 | |
| SCHEMBL14065408 | 0.77 | HTT (0.41) | CA1CA2PIM1ALOX15ADORA2A | |
| SCHEMBL20051812 | 0.76 | XDH (0.52) | ADORA2AADORA1XDH | |
| SCHEMBL29614873 | 0.76 | XDH (0.52) | ADORA2AADORA1XDH | |
| SCHEMBL4828417 | 0.75 | PLAU (0.39) | — | |
| SCHEMBL28559290 | 0.72 | ATR (0.44) | ADORA2AADORA2BADORA1 | |
| SCHEMBL29045675 | 0.71 | LTA4H (0.51) | ADORA2A | |
| SCHEMBL4084268 | 0.71 | CA1 (0.53) | CA1CA2CDC7CDK2MYB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429607-B2 | 5-HT2B receptor antagonists | ASTERAND UK LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| US-7429607-B2 | 5-HT2B receptor antagonists | ASTERAND UK LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| EP-1474140-B1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | ASTERAND UK LTD (GB) | 2007-11-21 | — | — | EP | disclosed |