SCHEMBL14066570

SCHEMBL14066570

Cc1cc(-c2ccc(Cl)cc2)cc(C)c1C1=C(OC(=O)OC(C)C)C(C)(C)C(C)(C)OC1=O

nearest known ligand 0.31

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31
CYP2C19 P33261 1/20 0.31
PDCD1 Q15116 1/20 0.31
CD274 Q9NZQ7 1/20 0.31
ACACB O00763 1/20 0.31
ACACA Q13085 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14066725 0.88 MAPT (0.32) PTGS2ALDH1A1ACACBACACAKMT2A
SCHEMBL823041 0.79 ALDH1A1 (0.33) ALDH1A1CYP1A2CYP3A4CYP2C9HPGD
SCHEMBL812008 0.79 ACACB (0.30) ALDH1A1CYP1A2CYP3A4CYP2C9HPGD
SCHEMBL13359403 0.78 MMP1 (0.33) ALDH1A1CYP1A2CYP3A4CYP2C9HPGD
SCHEMBL812037 0.77 PGR (0.34) PTGS2ALDH1A1ACACBACACAKMT2A
SCHEMBL14066574 0.77 ACACB (0.38) PTGS2ALDH1A1CYP1A2CYP2C19ACACB
SCHEMBL14066722 0.72 ACACB (0.36) PTGS2ACACBACACA
SCHEMBL812007 0.70 PGR (0.40) PTGS2ALDH1A1ACACBACACAMEN1
SCHEMBL811909 0.67 ACACB (0.38) ALDH1A1HPGDACACBACACAMEN1
SCHEMBL812048 0.65 LMNA (0.38) ALDH1A1ACACBACACAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1303505-B1 PHENYL-SUBSTITUTED 5,6-DIHYDROPYRONE DERIVATIVES FOR USE AS PESTICIDES AND HERBICIDES BAYER CROPSCIENCE AG (DE) 2008-09-03 EP disclosed