Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.53 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011364 | 0.78 | PNP (0.54) | HRH3HRH4PNPTSHRLMNA | |
| SCHEMBL14123256 | 0.76 | SMN1; SMN2 (0.60) | HRH3HRH4PNPL3MBTL1TSHR | |
| SCHEMBL12578976 | 0.72 | HRH3 (0.59) | HRH3HRH4L3MBTL1HRH1TSHR | |
| SCHEMBL41191 | 0.71 | L3MBTL1 (0.59) | HRH3HRH4L3MBTL1HRH1TSHR | |
| SCHEMBL29830938 | 0.71 | L3MBTL1 (0.59) | HRH3HRH4L3MBTL1HRH1TSHR | |
| Bromide SCHEMBL6114859 | 0.69 | L3MBTL1 (0.57) | HRH3HRH4L3MBTL1HRH1TSHR | |
| Ammonia Solution, Strong SCHEMBL6176560 | 0.69 | L3MBTL1 (0.57) | HRH3HRH4L3MBTL1HRH1TSHR | |
| SCHEMBL29715188 | 0.69 | L3MBTL1 (0.57) | HRH3HRH4L3MBTL1HRH1TSHR | |
| SCHEMBL4938201 | 0.69 | L3MBTL1 (0.57) | HRH3HRH4L3MBTL1HRH1TSHR | |
| Hydrochloric Acid SCHEMBL10884973 | 0.69 | L3MBTL1 (0.57) | HRH3HRH4L3MBTL1HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221152-A1 | 4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS | ALLERGAN, INC. (US) | 2008-09-11 | — | — | US | disclosed |
| US-7399868-B2 | 4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists | ALLERGAN, INC. (US) | 2008-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221152-A1 | 4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS | ADRB2, ADRA2C, ADRA2A | HRH3 498/4885HRH4 355/4885PNP 3920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.