Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 4/20 | 0.60 |
| ▸ | NR2C2 | P49116 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | HCK | P08631 | 2/20 | 0.56 |
| ▸ | GCK | P35557 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069850 | 0.93 | KIT (0.61) | EGFRBRAFBTKKIT | |
| SCHEMBL14070274 | 0.84 | BRAF (0.57) | BRAFBTK | |
| SCHEMBL14069584 | 0.84 | LYN (0.59) | BRAFBTKHCK | |
| SCHEMBL4699786 | 0.80 | BRAF (0.63) | EGFRBRAFKIT | |
| SCHEMBL4879660 | 0.80 | EGFR (0.58) | EGFRBRAFBTKNR2C2MAPK1 | |
| SCHEMBL14069588 | 0.79 | BTK (0.67) | EGFRBRAFBTKMAPK1ATM | |
| SCHEMBL2280193 | 0.79 | RAD52 (0.75) | EGFRBRAFBTKNR2C2MAPK1 | |
| SCHEMBL2226481 | 0.78 | HTT (0.68) | EGFRBRAFBTKNR2C2MAPK1 | |
| SCHEMBL14069589 | 0.78 | BRAF (0.54) | BRAFBTKHCK | |
| SCHEMBL14070288 | 0.77 | BTK (0.55) | EGFRBRAFBTKMAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |