Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 7/20 | 0.61 |
| ▸ | CSF1R | P07333 | 5/20 | 0.61 |
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | BRAF | P15056 | 4/20 | 0.59 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | BCR | P11274 | 2/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069849 | 0.93 | EGFR (0.61) | KITEGFRBRAFBTK | |
| SCHEMBL14070274 | 0.83 | BRAF (0.57) | CSF1RBRAFBTK | |
| SCHEMBL14069588 | 0.79 | BTK (0.67) | KITCSF1REGFRBRAFABL1 | |
| SCHEMBL22025471 | 0.79 | ABL1 (0.68) | KITCSF1REGFRBRAFABL1 | |
| SCHEMBL4249619 | 0.78 | KIT (0.63) | KITCSF1REGFRBRAFABL1 | |
| SCHEMBL4699786 | 0.78 | BRAF (0.63) | KITCSF1REGFRBRAFABL1 | |
| SCHEMBL14070288 | 0.77 | BTK (0.55) | KITCSF1REGFRBRAFABL1 | |
| SCHEMBL4256157 | 0.77 | KIT (0.64) | KITCSF1REGFRBRAFABL1 | |
| SCHEMBL14070062 | 0.77 | BTK (0.54) | KITCSF1REGFRBRAFABL1 | |
| SCHEMBL3560129 | 0.76 | ABL1 (0.86) | KITBRAFABL1LYNBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |