Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | HCK | P08631 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 12/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.41 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.41 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.41 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.41 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.41 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.41 |
| ▸ | AGPS | O00116 | 1/20 | 0.41 |
| ▸ | MYO1F | O00160 | 1/20 | 0.41 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.41 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14070288 | 0.84 | BTK (0.55) | BTKINSRLCKLYNHCK | |
| SCHEMBL14069854 | 0.82 | CSF1R (0.59) | BTKINSRLCKLYNHCK | |
| SCHEMBL14069588 | 0.81 | BTK (0.67) | BTKINSRLCKLYNHCK | |
| SCHEMBL4786461 | 0.81 | BRAF (0.62) | BTKINSRLCKLYNHCK | |
| SCHEMBL14069583 | 0.80 | CSF1R (0.58) | BTKINSRLCKLYNHCK | |
| SCHEMBL14070218 | 0.78 | CSF1R (0.53) | BTKINSRLCKLYNHCK | |
| SCHEMBL14069584 | 0.78 | LYN (0.59) | BTKINSRLCKLYNHCK | |
| SCHEMBL14069589 | 0.78 | BRAF (0.54) | BTKINSRLCKLYNHCK | |
| SCHEMBL14069850 | 0.77 | KIT (0.61) | BTKLYNCSF1RBRAFKIT | |
| SCHEMBL14070268 | 0.76 | BTK (0.51) | BTKINSRLCKLYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |