SCHEMBL140742

SCHEMBL140742

CC([SiH3])=Cc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.54
TSHR P16473 1/20 0.54
AKR1C3 P42330 1/20 0.54
FBP1 P09467 1/20 0.48
KDM1A O60341 1/20 0.45
RECQL P46063 1/20 0.45
HTT P42858 1/20 0.44
GLA P06280 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
DHODH Q02127 1/20 0.42
TRPM8 Q7Z2W7 1/20 0.42
AKR1C1 Q04828 1/20 0.41
ESR1 P03372 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
MAPT P10636 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ALOX15 P16050 1/20 0.40
MTNR1A P48039 1/20 0.40
MTNR1B P49286 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8072809 0.80 ALDH1A1 (0.48) ALDH1A1TSHRAKR1C3FBP1KDM1A
SCHEMBL23045161 0.78 ALDH1A1 (0.43) ALDH1A1TSHRAKR1C3FBP1KDM1A
SCHEMBL8557597 0.78 ALDH1A1 (0.58) ALDH1A1TSHRAKR1C3FBP1KDM1A
SCHEMBL60657 0.78 ALDH1A1 (0.58) ALDH1A1TSHRAKR1C3FBP1KDM1A
SCHEMBL23458002 0.78 AKR1C3 (0.73) ALDH1A1TSHRAKR1C3FBP1KDM1A
SCHEMBL6433811 0.78 AKR1C3 (0.73) ALDH1A1TSHRAKR1C3FBP1KDM1A
SCHEMBL598776 0.78 ALDH1A1 (0.58) ALDH1A1TSHRAKR1C3FBP1KDM1A
SCHEMBL1826883 0.77 AKR1C3 (0.52) ALDH1A1TSHRAKR1C3FBP1KDM1A
SCHEMBL11801120 0.76 ALDH1A1 (0.56) ALDH1A1TSHRAKR1C3FBP1KDM1A
Ammonia Solution, Strong SCHEMBL28447731 0.76 ALDH1A1 (0.56) ALDH1A1TSHRAKR1C3FBP1KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170143763-A1 ORALLY ADMINISTERED ADSORBENT, THERAPEUTIC AGENT FOR RENAL DISEASE, AND THERAPEUTIC AGENT FOR LIVER DISEASE KUREHA CORPORATION (JP) 2017-05-25 US disclosed
WO-2014131701-A1 ADDITIVES FOR HYDROLYSIS STABILIZATION OF POLYMERS BASF SE (DE) 2014-09-04 WO disclosed
US-20140243477-A1 ADDITIVES FOR STABILIZING POLYMERS WITH RESPECT TO HYDROLYSIS BASF SE (DE) 2014-08-28 US disclosed
US-8623983-B2 Terpolymer of electron-deficient olefins, olefins without electron-withdrawing substituents, and alkoxyvinylsilanes BASF SE (DE) 2014-01-07 US disclosed
EP-2614092-A1 TERPOLYMER FORMED FROM ELECTRON-DEFICIENT OLEFINS, OLEFINS WITHOUT ELECTRON-WITHDRAWING SUBSTITUENTS AND ALKOXYVINYLSILANES BASF SE (DE) 2013-07-17 EP disclosed
WO-2012032005-A1 TERPOLYMER FORMED FROM ELECTRON-DEFICIENT OLEFINS, OLEFINS WITHOUT ELECTRON-WITHDRAWING SUBSTITUENTS AND ALKOXYVINYLSILANES BASF SE (DE) 2012-03-15 WO disclosed
US-20120059101-A1 TERPOLYMER OF ELECTRON-DEFICIENT OLEFINS, OLEFINS WITHOUT ELECTRON-WITHDRAWING SUBSTITUENTS, AND ALKOXYVINYLSILANES BASF SE (DE) 2012-03-08 US disclosed
US-4120937-A Process for the production of halosilicon acids and organic silicon acid compounds and resinous products BLOUNT DAVID H 1978-10-17 US disclosed