Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 1/20 | 1.00 |
| ▸ | TRPM2 | O94759 | 3/20 | 0.79 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.73 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.73 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.73 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.73 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 4/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366850 | 1.00 | KCNK2 (1.00) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL29862876 | 1.00 | KCNK2 (1.00) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL6787369 | 0.90 | KCNK2 (0.81) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL6787364 | 0.90 | KCNK2 (0.81) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL28947494 | 0.88 | TRPM2 (1.00) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL28947495 | 0.88 | TRPM2 (1.00) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL16438113 | 0.87 | KCNK2 (0.77) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL29050647 | 0.86 | CYSLTR2 (0.78) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL30218660 | 0.84 | CYSLTR2 (1.00) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 | |
| SCHEMBL1895053 | 0.84 | CYSLTR2 (1.00) | KCNK2TRPM2CYSLTR2CYSLTR1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114831977-A | Application of benzoic acid derivatives as TRPM2 protein inhibitors | 北京大学 | 2022-08-02 | — | — | CN | claimed |
| EP-1238099-A2 | AUTOMATED LYSOPHOSPHOLIPID ASSAY AND METHODS OF DETECTING CANCER | ABBOTT LABORATORIES (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001032916-A2 | AUTOMATED LYSOPHOSPHOLIPID ASSAY AND METHODS OF DETECTING CANCER | ABBOTT LABORATORIES (US) | 2001-05-10 | — | — | WO | claimed |
| CN-114831977-B | Application of benzoic acid derivative as TRPM2 protein inhibitor | 北京大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-114831977-A | Application of benzoic acid derivatives as TRPM2 protein inhibitors | 北京大学 | 2022-08-02 | — | — | CN | disclosed |
| US-11077109-B2 | Compounds having antibacterial activity and methods of use | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2021-08-03 | — | — | US | disclosed |
| US-20190201401-A1 | COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY AND METHODS OF USE | THE TRUSTEES OF PRINCETON UNIVERSITY | 2019-07-04 | — | — | US | disclosed |
| US-20150099800-A1 | NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF | NIH - DEITR | 2015-04-09 | — | — | US | disclosed |
| WO-2013177492-A2 | NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF | NORTHEASTERN UNIVERSITY (US) | 2013-11-28 | — | — | WO | disclosed |
| WO-2013151735-A1 | METHOD TO MITIGATE LONG-QT ARRHYTHMIAS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-10-10 | — | — | WO | disclosed |
| US-20100009970-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2010-01-14 | — | — | US | disclosed |
| EP-0702725-A4 | METHOD FOR RECOMBINANT PRODUCTION OF BIOLOGICALLY ACTIVE POLYPEPTIDES | JOLLA INST ALLERGY IMMUNOLOG (US) | 1998-09-30 | — | — | EP | disclosed |
| US-5786168-A | CULTURING EUKARYOTIC CELLS TRANSFORMED WITH POLYNUCLEOTIDE SEQUENCE ENCODING A FUSION POLYPEPTIDE | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-07-28 | — | — | US | disclosed |
| US-5723582-A | IMMUNOLOGY AND AUTOIMMUNE DISEASES | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) | 1998-03-03 | — | — | US | disclosed |
| US-5565338-A | Suppressor T-cell hybridoma and production of allergen specific glycosylation inhibiting factor | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0702725-A1 | METHOD FOR RECOMBINANT PRODUCTION OF BIOLOGICALLY ACTIVE POLYPEPTIDES | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) | 1996-03-27 | — | — | EP | disclosed |
| WO-1994026923-A1 | METHOD FOR RECOMBINANT PRODUCTION OF BIOLOGICALLY ACTIVE POLYPEPTIDES | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) | 1994-11-24 | — | — | WO | disclosed |
| EP-0591320-A4 | SUPPRESSOR T-CELL HYBRIDOMA. | JOLLA INST ALLERGY IMMUNOLOG (US) | 1994-11-23 | — | — | EP | disclosed |
| EP-0591320-A1 | SUPPRESSOR T-CELL HYBRIDOMA | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1992021240-A1 | SUPPRESSOR T-CELL HYBRIDOMA | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) | 1992-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009970-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | HTR1A, HTR3B, HTR3A | KCNK2 1772/4885TRPM2 3142/4885CYSLTR2 3511/4885 |
| US-20190201401-A1 | COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY AND METHODS OF USE | MMP8, MRPL21, CLPP | KCNK2 4452/4885TRPM2 1997/4885CYSLTR2 1959/4885 |
| US-20150099800-A1 | NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF | PNLIP, LIPE, LIPC | KCNK2 4281/4885TRPM2 1955/4885CYSLTR2 1981/4885 |
| US-11077109-B2 | Compounds having antibacterial activity and methods of use | MMP8, MRPL21, CLPP | KCNK2 4452/4885TRPM2 1997/4885CYSLTR2 1959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.