Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.43 |
| ▸ | DRD2 | P14416 | 9/20 | 0.43 |
| ▸ | HTR2A | P28223 | 9/20 | 0.43 |
| ▸ | DRD3 | P35462 | 9/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 4/20 | 0.42 |
| ▸ | DRD5 | P21918 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15013797 | 0.86 | HTR1A (0.47) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL5252015 | 0.78 | CA2 (0.55) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL4654113 | 0.78 | HTR1A (0.43) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL2566343 | 0.78 | HTR1A (0.43) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL5979697 | 0.78 | HTR1A (0.43) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL424976 | 0.78 | MAOA (0.53) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL5636661 | 0.78 | DRD2 (0.45) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL5694454 | 0.77 | MAOA (0.47) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL7823518 | 0.77 | HTR1A (0.42) | HTR1ADRD2HTR2ADRD3HTR7 | |
| SCHEMBL10483962 | 0.75 | DRD2 (0.43) | HTR1ADRD2HTR2ADRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776356-B1 | ALKYL-AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATES | BOEHRINGER INGELHEIM INT (DE) | 2008-09-17 | — | — | EP | disclosed |