Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943418 | 0.92 | KDM4E (0.46) | DRD2DRD4DRD3HTR1AKDM4E | |
| SCHEMBL11946604 | 0.89 | CHRM4 (0.39) | DRD2HTR1AKDM4EALDH1A1KMT2A | |
| SCHEMBL11943369 | 0.88 | ALDH1A1 (0.41) | KDM4EALDH1A1ALOX15TSHRKMT2A | |
| SCHEMBL11943461 | 0.85 | MAPT (0.38) | DRD2DRD4HTR7KDM4EALDH1A1 | |
| SCHEMBL14082720 | 0.85 | LMNA (0.35) | DRD2DRD4HTR7DRD3HTR1A | |
| SCHEMBL11943444 | 0.85 | NPBWR1 (0.43) | DRD4ALDH1A1KMT2ALMNADCTPP1 | |
| SCHEMBL11943355 | 0.84 | BCL2L1 (0.44) | DRD2DRD3KMT2ALMNAMAPT | |
| SCHEMBL11943445 | 0.84 | ALDH1A1 (0.49) | DRD2DRD4DRD3KDM4EALDH1A1 | |
| SCHEMBL11943356 | 0.84 | NPC1 (0.40) | DRD2DRD3ALDH1A1KMT2ALMNA | |
| SCHEMBL11943381 | 0.84 | FAAH (0.43) | DRD2DRD3KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |