Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942534 | 0.87 | NPC1 (0.70) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL13942543 | 0.86 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6030180 | 0.84 | ALDH1A1 (0.66) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL13942545 | 0.84 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL13304485 | 0.79 | NPC1 (0.65) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL8237031 | 0.78 | MAPT (0.51) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL17057998 | 0.77 | NPC1 (0.50) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL14082616 | 0.77 | HTR1A (0.52) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL17058099 | 0.77 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL14081526 | 0.77 | ALDH1A1 (0.56) | RAB9ANPC1SMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115385-A2 | PIPERAZINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |