Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943326 | 0.91 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4EDCTPP1RXFP1 | |
| SCHEMBL11943338 | 0.87 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EDCTPP1RXFP1 | |
| SCHEMBL11943471 | 0.86 | ALDH1A1 (0.50) | MAPTALDH1A1KDM4EDCTPP1RXFP1 | |
| SCHEMBL11943549 | 0.84 | POLB (0.45) | MAPTALDH1A1KDM4EDCTPP1RXFP1 | |
| SCHEMBL11943824 | 0.83 | MAPT (0.40) | MAPTALDH1A1KDM4EDCTPP1RXFP1 | |
| SCHEMBL11943815 | 0.83 | NPC1 (0.46) | MAPTALDH1A1KDM4EDCTPP1RXFP1 | |
| SCHEMBL11943814 | 0.80 | NPBWR1 (0.47) | MAPTALDH1A1KDM4EDCTPP1RXFP1 | |
| SCHEMBL11943104 | 0.80 | NPC1 (0.54) | MAPTALDH1A1KDM4EDCTPP1CA12 | |
| SCHEMBL11943415 | 0.79 | DRD2 (0.47) | MAPTALDH1A1KDM4EDCTPP1RXFP1 | |
| SCHEMBL11943816 | 0.79 | LMNA (0.51) | MAPTALDH1A1KDM4EDCTPP1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115385-A2 | PIPERAZINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |