Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.60 |
| ▸ | WNT1 | P04628 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14082526 | 0.99 | SMN1; SMN2 (0.61) | DYRK1AWNT1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14082527 | 0.93 | NPC1 (0.69) | DYRK1AWNT1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14082548 | 0.85 | DYRK1A (0.63) | DYRK1AWNT1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10143960 | 0.84 | ALDH1A1 (0.77) | SMN1; SMN2NPC1RAB9ALMNATSHR | |
| SCHEMBL4414127 | 0.84 | ALDH1A1 (0.77) | SMN1; SMN2NPC1RAB9ALMNATSHR | |
| SCHEMBL2983895 | 0.84 | NPC1 (0.84) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL22289346 | 0.84 | NPC1 (0.84) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL22308180 | 0.84 | NPC1 (0.84) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL517178 | 0.84 | NPC1 (0.74) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL518043 | 0.84 | NPC1 (0.74) | SMN1; SMN2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | DYRK1A 4872/4885WNT1 4439/4885SMN1; SMN2 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.