Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.66 |
| ▸ | KDM1A | O60341 | 7/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LSS | P48449 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14082607 | 0.86 | HDAC1 (0.72) | HDAC1KDM1ALSSHDAC2HDAC8 | |
| SCHEMBL14082625 | 0.86 | HDAC1 (0.69) | HDAC1KDM1AHDAC4HDAC6ROCK2 | |
| SCHEMBL14082732 | 0.85 | HDAC1 (0.66) | HDAC1KDM1AALDH1A1LSSHDAC2 | |
| SCHEMBL14082296 | 0.85 | KDM4E (0.65) | HDAC1KDM1AHDAC4KDM4EALDH1A1 | |
| SCHEMBL14082650 | 0.83 | MLYCD (0.67) | HDAC1KDM1AROCK2ROCK1 | |
| SCHEMBL14082686 | 0.82 | HDAC1 (0.64) | HDAC1KDM1AHDAC4HDAC2HDAC8 | |
| SCHEMBL14082684 | 0.82 | HDAC1 (0.63) | HDAC1KDM1AHDAC2HDAC8HDAC6 | |
| SCHEMBL14082666 | 0.81 | HDAC1 (0.58) | HDAC1KDM1AHDAC4ALDH1A1HDAC2 | |
| SCHEMBL14082165 | 0.80 | KDM4E (0.61) | HDAC1KDM1AHDAC4KDM4EALDH1A1 | |
| SCHEMBL14082729 | 0.80 | KDM1A (0.61) | HDAC1KDM1AALDH1A1HTTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | HDAC1 556/4885KDM1A 4497/4885HDAC4 794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.