SCHEMBL140841

SCHEMBL140841

O=Cc1ccc(OC(F)F)c(OC(F)F)c1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 3/20 0.53
ALDH1A1 P00352 6/20 0.52
TSHR P16473 1/20 0.52
PDE4B Q07343 6/20 0.44
FDPS P14324 1/20 0.44
KDM4E B2RXH2 1/20 0.44
HTT P42858 1/20 0.44
AOX1 Q06278 1/20 0.43
TRIM24 O15164 1/20 0.43
HPGD P15428 1/20 0.43
ALDH5A1 P51649 1/20 0.43
ABAT P80404 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
TRIM33 Q9UPN9 1/20 0.43
TTR P02766 1/20 0.41
PDE4A P27815 2/20 0.41
PDE4C Q08493 2/20 0.41
PDE4D Q08499 2/20 0.41
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29440132 1.00 DRD1 (0.53) DRD1ALDH1A1TSHRPDE4BFDPS
SCHEMBL7538876 0.91 ALDH1A1 (0.49) DRD1ALDH1A1TSHRPDE4BFDPS
SCHEMBL1966450 0.89 ALDH1A1 (0.70) DRD1ALDH1A1TSHRPDE4BFDPS
SCHEMBL140472 0.89 ALDH1A1 (0.70) DRD1ALDH1A1TSHRPDE4BFDPS
SCHEMBL7869796 0.86 DRD1 (0.46) DRD1ALDH1A1TSHRPDE4BFDPS
SCHEMBL31619160 0.85 ALDH1A1 (0.58) DRD1ALDH1A1TSHRPDE4BFDPS
SCHEMBL1143785 0.85 ALDH1A1 (0.58) DRD1ALDH1A1TSHRPDE4BFDPS
SCHEMBL5758960 0.85 DRD1 (0.48) DRD1ALDH1A1TSHRPDE4BPDE4A
SCHEMBL24036560 0.85 DRD1 (0.50) DRD1ALDH1A1TSHRPDE4BFDPS
SCHEMBL30028575 0.85 DRD1 (0.50) DRD1ALDH1A1TSHRPDE4BFDPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025122684-A1 PARTIALLY FLUORINATED ARYL ETHER SURFACTANT COMPOSITIONS AND METHODS OF USE THE CHEMOURS COMPANY FC, LLC (US) 2025-06-12 WO disclosed
EP-2947073-B1 FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS FIBROTECH THERAPEUTICS PTY LTD (AU) 2019-04-03 EP disclosed
EP-3045170-B1 HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS FIBROTECH THERAPEUTICS PTY LTD (AU) 2018-07-04 EP disclosed
EP-3045170-B1 HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS FIBROTECH THERAPEUTICS PTY LTD (AU) 2018-07-04 EP disclosed
US-9951087-B2 Fused ring analogues of anti-fibrotic agents FIBROTECH THERAPEUTICS PTY LTD (AU) 2018-04-24 US disclosed
EP-2323985-B1 TRIPYRIDYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS MERCK SHARP & DOHME (US) 2017-01-11 EP disclosed
EP-2323985-B1 TRIPYRIDYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS MERCK SHARP & DOHME (US) 2017-01-11 EP disclosed
EP-3045170-A1 HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS Fibrotech Therapeutics PTY LTD (AU) 2016-07-20 EP disclosed
EP-3045170-A1 HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS Fibrotech Therapeutics PTY LTD (AU) 2016-07-20 EP disclosed
CN-105732348-A Synthesis method of 3-hydroxyl-4-difluoromethoxyl benzaldehyde 中国科学院成都有机化学有限公司 2016-07-06 CN disclosed
WO-1995001338-A1 FLUOROALKOXY-SUBSTITUTED BENZAMIDES AND THEIR USE AS CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1995-01-12 WO disclosed
WO-1993019750-A1 COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES SMITHKLINE BEECHAM CORPORATION (US) 1993-10-14 WO disclosed
WO-1993019751-A1 COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR SMITHKLINE BEECHAM CORPORATION (US) 1993-10-14 WO disclosed
US-4596880-A Pesticides BAYER AKTIENGESELLSCHAFT (DE) 1986-06-24 US disclosed
EP-0006978-B1 BENZYL ESTERS WITH FLUORINATED ETHER AND/OR THIOETHER GROUPS, THEIR PREPARATIONS AND THEIR USE AS INSECTICIDES; INTERMEDIATE PRODUCTS AND THEIR PREPARATIONS BAYER AG (DE) 1986-01-29 EP disclosed
EP-0041131-B1 PREPARATION OF FLUORO-SUBSTITUTED BENZODIOXOLES AND BENZODIOXANES BAYER AG (DE) 1984-06-13 EP disclosed
US-4438275-A 2,2-DIFLUORO-BENZODIOXOLES BAYER AKTIENGESELLSCHAFT (DE) 1984-03-20 US disclosed
US-4310540-A PYRETHROID-LIKE COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1982-01-12 US disclosed
EP-0041131-A2 Preparation of fluoro-substituted benzodioxoles and benzodioxanes BAYER AG (DE) 1981-12-09 EP disclosed
EP-0006978-A2 Benzyl esters with fluorinated ether and/or thioether groups, their preparations and their use as insecticides; intermediate products and their preparations BAYER AG (DE) 1980-01-23 EP disclosed