Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | EP300 | Q09472 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15213457 | 0.80 | ACHE (0.37) | ALDH1A1KDM4ESMN1; SMN2MAPK1EP300 | |
| SCHEMBL11765896 | 0.78 | ACHE (0.35) | ALDH1A1KDM4ESMN1; SMN2MAPK1EP300 | |
| SCHEMBL5751135 | 0.78 | ACHE (0.43) | ALDH1A1KDM4ESMN1; SMN2MAPK1EP300 | |
| SCHEMBL3670998 | 0.74 | ACHE (0.35) | ALDH1A1KDM4ESMN1; SMN2MAPK1EP300 | |
| SCHEMBL5746719 | 0.73 | ALDH1A1 (0.75) | ALDH1A1KDM4ESMN1; SMN2MAPK1EP300 | |
| SCHEMBL9312315 | 0.71 | KDM4E (0.42) | ALDH1A1KDM4ESMN1; SMN2MAPK1POLB | |
| SCHEMBL30598970 | 0.70 | ALDH1A1 (0.61) | ALDH1A1KDM4ESMN1; SMN2MAPK1EP300 | |
| SCHEMBL11476309 | 0.70 | ALDH1A1 (0.61) | ALDH1A1KDM4ESMN1; SMN2MAPK1EP300 | |
| SCHEMBL2317562 | 0.70 | TP53 (0.45) | ALDH1A1KDM4ESMN1; SMN2MAPK1TDP1 | |
| SCHEMBL29853674 | 0.70 | TP53 (0.45) | ALDH1A1KDM4ESMN1; SMN2MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1034221-B1 | DIBENZORHODAMINE DYES USEFUL AS FLUORESCENT LABELLING AGENTS | LIFE TECHNOLOGIES CORP (US) | 2014-05-14 | — | — | EP | disclosed |
| US-20110124510-A1 | METHODS OF LABELING POLYNUCLEOTIDE WITH DIBENZORHODAMINE DYES | Life Technologies Corporation (US) | 2011-05-26 | — | — | US | disclosed |
| EP-2295503-A1 | Dibenzorhodamine dyes useful as fluorescent labelling agents | Applera Corporation (US) | 2011-03-16 | — | — | EP | disclosed |
| US-7833756-B2 | Methods of labelling polynucleotides with dibenzorhodamine dyes | APPLIED BIOSYSTEMS, LLC (US) | 2010-11-16 | — | — | US | disclosed |
| EP-2221347-A1 | Sulfonated diarylrhodamine dyes | Applera Corporation (US) | 2010-08-25 | — | — | EP | disclosed |
| EP-2186801-A2 | Intermediates for synthesizing dibenzorhodamine dyes | Applera Corporation (US) | 2010-05-19 | — | — | EP | disclosed |
| EP-2179996-A1 | Sulfonated diarylrhodamine dyes | Applera Corporation (US) | 2010-04-28 | — | — | EP | disclosed |
| US-20090068751-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | APPLIED BIOSYSTEMS INC. (US) | 2009-03-12 | — | — | US | disclosed |
| US-20070099210-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | APPLERA CORPORATION (US) | 2007-05-03 | — | — | US | disclosed |
| US-7018431-B2 | Sulfonated diarylrhodamine dyes | APPLERA CORPORATION (US) | 2006-03-28 | — | — | US | disclosed |
| EP-1408090-A1 | Dibenzorhodamine dyes useful as fluorescent labelling agents | Applera Corporation (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6583168-B1 | Fluorescent labels of nucleosides, nucleotides, polynucleotides, and polypeptides in nucleic acid analysis | APPLERA CORPORATION | 2003-06-24 | — | — | US | disclosed |
| US-6566071-B2 | Useful as fluorescent labeling reagents | APPLERA CORPORATION | 2003-05-20 | — | — | US | disclosed |
| US-20020034761-A1 | Methods of labelling polynucleotides with dibenzorhodamine dyes | THE PERKIN-ELMER CORPORATION (US) | 2002-03-21 | — | — | US | disclosed |
| US-6326153-B2 | POLYNUCLEOTIDE SEQUENCING | THE PERKIN-ELMER CORPORATION | 2001-12-04 | — | — | US | disclosed |
| US-20010011139-A1 | Polynucleotides labeled with dibenzorhodamine dyes | THE PERKIN-ELMER CORPORATION | 2001-08-02 | — | — | US | disclosed |
| US-6221606-B1 | ENERGY TRANSFER DYE COMPRISING A DONOR DYE WHICH ABSORBS IGHT AND EMITS EXITATION ENERGY, AN ACCEPTOR DYE THE ABSORBS THE EXCITATION ENERGY AND FLUORESCES IN RESPONSE, AND A LINKER LINKING THE TWO DYES, AT LEAST ONE IS A DIBENZORHODAMINE DYE | THE PERKIN-ELMER CORPORATION | 2001-04-24 | — | — | US | disclosed |
| US-6111116-A | FLUORESCENT LABELING REAGENTS | THE PERKIN-ELMER CORPORATION (US) | 2000-08-29 | — | — | US | disclosed |
| US-6051719-A | FLUORESCENT LABELING REAGENTS | THE PERKIN-ELMER CORPORATION (US) | 2000-04-18 | — | — | US | disclosed |
| US-5936087-A | FLUORESCENT LABELS; DNA SEQUENCING | THE PERKIN-ELMER CORPORATION (US) | 1999-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020034761-A1 | Methods of labelling polynucleotides with dibenzorhodamine dyes | NUDT1, DUT, NSUN2 | ALDH1A1 1831/4885KDM4E 3960/4885SMN1; SMN2 1068/4885 |
| US-20010011139-A1 | Polynucleotides labeled with dibenzorhodamine dyes | NUDT1, DNTT, DUT | ALDH1A1 1223/4885KDM4E 4648/4885SMN1; SMN2 872/4885 |
| US-20090068751-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | NUDT1, DUT, NSUN3 | ALDH1A1 1629/4885KDM4E 3602/4885SMN1; SMN2 1538/4885 |
| US-20070099210-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | NUDT1, DUT, NSUN3 | ALDH1A1 1645/4885KDM4E 3782/4885SMN1; SMN2 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.