Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 10/20 | 0.44 |
| ▸ | CTSK | P43235 | 10/20 | 0.44 |
| ▸ | CTSB | P07858 | 4/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14583981 | 0.86 | KLKB1 (0.47) | CA1CA2KLKB1PSMB8PSMB9 | |
| SCHEMBL12340141 | 0.82 | CTSS (0.57) | CA1CA2KLKB1CTSSCTSK | |
| SCHEMBL12340145 | 0.79 | CTSS (0.53) | CA1CA2KLKB1CTSSCTSK | |
| SCHEMBL14583979 | 0.79 | KLKB1 (0.43) | KLKB1PSMB8PSMB9PSMB5PSMB1 | |
| SCHEMBL14485298 | 0.78 | ATM (0.53) | CA1CA2CTSSCTSKCTSB | |
| SCHEMBL14485300 | 0.78 | ATM (0.53) | CA1CA2CTSSCTSKCTSB | |
| SCHEMBL3584002 | 0.78 | CTSK (0.50) | CA1CA2CTSSCTSKCTSB | |
| SCHEMBL2921238 | 0.78 | CTSK (0.50) | CA1CA2CTSSCTSKCTSB | |
| SCHEMBL3188590 | 0.77 | CTSK (0.60) | CA1CA2CTSSCTSKCTSB | |
| SCHEMBL22236519 | 0.77 | CTSS (0.63) | CA1CA2CTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417030-B2 | Indazole peptidomimetics as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7417030-B2 | Indazole peptidomimetics as thrombin receptor antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-08-26 | — | — | US | disclosed |