Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | MDM4 | O15151 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14092479 | 0.88 | CYP19A1 (0.44) | CYP19A1CYP11B1CYP11B2CYP1A2ALPI | |
| SCHEMBL13803056 | 0.88 | CYP19A1 (0.44) | CYP19A1CYP11B1CYP11B2ALPINPC1 | |
| SCHEMBL14092475 | 0.88 | CYP19A1 (0.44) | CYP19A1CYP11B1CYP11B2CYP1A2ALPI | |
| SCHEMBL14092391 | 0.84 | NR3C1 (0.44) | CYP19A1CYP11B1CYP11B2CYP1A2ALPI | |
| SCHEMBL14092387 | 0.84 | NR3C1 (0.44) | CYP19A1CYP11B1CYP11B2CYP1A2ALPI | |
| SCHEMBL14092471 | 0.83 | CYP19A1 (0.48) | CYP19A1CYP11B1CYP11B2CYP1A2LMNA | |
| SCHEMBL14092466 | 0.83 | CYP19A1 (0.48) | CYP19A1CYP11B1CYP11B2CYP1A2LMNA | |
| SCHEMBL14092468 | 0.81 | NR3C1 (0.56) | CYP19A1CYP11B1CYP11B2CYP1A2TP53 | |
| SCHEMBL14092473 | 0.81 | NR3C1 (0.56) | CYP19A1CYP11B1CYP11B2CYP1A2TP53 | |
| SCHEMBL14092394 | 0.79 | CYP11B2 (0.45) | CYP19A1CYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |