Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.46 |
| ▸ | P2RX5 | Q93086 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4358758 | 0.78 | SIRT2 (0.57) | SIRT2SIRT1MAPTALDH1A1NPC1 | |
| SCHEMBL4369732 | 0.78 | SIRT2 (0.64) | SIRT2SIRT1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4368732 | 0.77 | SIRT1 (0.56) | SIRT2SIRT1MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL3718449 | 0.76 | SIRT2 (0.67) | SIRT2SIRT1MAPTALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL3718452 | 0.76 | SIRT2 (0.67) | SIRT2SIRT1MAPTALDH1A1TDP1 | |
| SCHEMBL16229389 | 0.76 | SIRT2 (0.86) | SIRT2SIRT1MAPTALDH1A1TDP1 | |
| SCHEMBL2872153 | 0.76 | SIRT2 (0.57) | SIRT2SIRT1MAPTALDH1A1NPC1 | |
| SCHEMBL4363717 | 0.76 | SIRT1 (0.55) | SIRT2SIRT1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4363690 | 0.76 | ALDH1A1 (0.63) | SIRT2SIRT1MAPTALDH1A1TDP1 | |
| SCHEMBL3145014 | 0.75 | SIRT2 (0.54) | SIRT2SIRT1MAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207760-A1 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv | ACHILLION PHARMACEUTICALS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| US-20080207760-A1 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv | ACHILLION PHARMACEUTICALS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207760-A1 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv | RNASE1, SARS1, EIF2AK2 | SIRT2 4612/4885SIRT1 4376/4885MAPT 4038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.