Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640425 | 0.91 | PARP1 (0.42) | KDM4EPARP1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL4640440 | 0.89 | PARP1 (0.41) | KDM4EPARP1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL4640372 | 0.78 | JAK2 (0.46) | KDM4EPARP1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL4642112 | 0.75 | KDM4E (0.46) | KDM4EPARP1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL4640351 | 0.74 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNAHSD17B10ERN1 | |
| SCHEMBL4740085 | 0.71 | PARP1 (0.50) | PARP1ERN1CYP2A6CREBBP | |
| SCHEMBL5032923 | 0.69 | PARP1 (0.49) | KDM4EPARP1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL3945829 | 0.68 | KDM4E (0.45) | KDM4EALDH1A1LMNAHSD17B10ERN1 | |
| SCHEMBL26462283 | 0.68 | LMNA (0.50) | KDM4EPARP1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL219830 | 0.68 | HTR3A (0.50) | KDM4EPARP1ALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956016-A1 | Bicyclic acyltryptophanols | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-08-13 | — | — | EP | disclosed |