Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.58 |
| ▸ | CPT2 | P23786 | 2/20 | 0.58 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59972 | 1.00 | ACLY (0.58) | ACLYCPT2HSPD1BLMHSPE1 | |
| SCHEMBL1462468 | 1.00 | ACLY (0.58) | ACLYCPT2HSPD1BLMHSPE1 | |
| Cadaverine Tartrate SCHEMBL9398238 | 0.89 | ACLY (0.59) | ACLYCPT2HSPD1BLMHSPE1 | |
| Malic Acid SCHEMBL29107079 | 0.84 | SMN1; SMN2 (0.54) | ACLYCPT2HSPD1BLMHSPE1 | |
| SCHEMBL13176929 | 0.83 | CPT2 (0.40) | ACLYCPT2HSPD1BLMHSPE1 | |
| SCHEMBL18283302 | 0.83 | ACLY (0.61) | ACLYCPT2HSPD1BLMHSPE1 | |
| Leucine SCHEMBL935696 | 0.82 | SLC7A5 (0.60) | ACLYCPT2HSPD1BLMHSPE1 | |
| SCHEMBL17632510 | 0.82 | ACLY (0.50) | ACLYCPT2HSPD1BLMHSPE1 | |
| Leucine SCHEMBL935695 | 0.82 | SLC7A5 (0.60) | ACLYCPT2HSPD1BLMHSPE1 | |
| SCHEMBL18283331 | 0.81 | CPT2 (0.39) | ACLYCPT2HSPD1BLMHSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12606850-B2 | Synthesis of beta-hydroxyisovalerate and methods of use | Sasya, Inc. (US) | 2026-04-21 | — | — | US | disclosed |
| US-12460234-B2 | Synthesis of isoprenoids and derivatives | WILLIAM MARSH RICE UNIVERSITY (US) | 2025-11-04 | — | — | US | disclosed |
| US-12338481-B2 | Method for producing 2-methyl-butyric acid by bacterial fermentation | AJINOMOTO CO., INC. (JP) | 2025-06-24 | — | — | US | disclosed |
| US-20250002949-A1 | SYNTHESIS OF BETA-HYDROXYISOVALERATE AND METHODS OF USE | Sasya Inc. | 2025-01-02 | — | — | US | disclosed |
| US-20240376483-A1 | RECOMBINANT MICROORGANISM AND L-LEUCINE PRODUCTION METHOD USING SAME | GREEN EARTH INSTITUTE CO., LTD. (JP) | 2024-11-14 | — | — | US | disclosed |
| EP-4092114-B1 | NOVEL 2-ISOPROPYLMALATE SYNTHASE VARIANT AND METHOD FOR PRODUCING L-VALINE USING SAME | CJ CHEILJEDANG CORP (KR) | 2024-08-28 | — | — | EP | disclosed |
| US-20240182932-A1 | SYNTHESIS OF ISOPRENOIDS AND DERIVATIVES | WILLIAM MARSH RICE UNIVERSITY (US) | 2024-06-06 | — | — | US | disclosed |
| EP-4034668-B1 | METHOD FOR PRODUCING 2-METHYL-BUTYRIC ACID BY BACTERIAL FERMENTATION | AJINOMOTO KK (JP) | 2024-04-17 | — | — | EP | disclosed |
| CN-117740961-A | Compound analysis method of liquorice and liquorice probiotics fermentation preparation | 北京中医药大学 | 2024-03-22 | — | — | CN | disclosed |
| US-11920177-B2 | Synthesis of beta-hydroxyisovalerate and methods of use | Sasya Inc. (US) | 2024-03-05 | — | — | US | disclosed |
| US-8311790-B2 | Reverse engineering genome-scale metabolic network reconstructions for organisms with incomplete genome annotation and developing constraints using proton flux states and numerically-determined sub-systems | UNIVERSITY OF DELAWARE (US) | 2012-11-13 | — | — | US | disclosed |
| WO-2011034397-A2 | METHOD FOR PREDICTING DRUG TARGETS AND SCREENING FOR DRUGS FOR PATHOGENIC MICROORGANISMS USING ESSENTIAL METABOLITES | 한국과학기술원 (KR) | 2011-03-24 | — | — | WO | disclosed |
| EP-2295593-A1 | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA | Marliere, Philippe (FR) | 2011-03-16 | — | — | EP | disclosed |
| US-20100304432-A1 | GENETICALLY MODIFIED BIOLOGICAL CELLS | O'KEEFE, THERESA | 2010-12-02 | — | — | US | disclosed |
| EP-2230312-A1 | Probe compound for detecting and isolating enzymes and means and methods using the same | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2010-09-22 | — | — | EP | disclosed |
| US-20090259451-A1 | REVERSE ENGINEERING GENOME-SCALE METABOLIC NETWORK RECONSTRUCTIONS FOR ORGANISMS WITH INCOMPLETE GENOME ANNOTATION AND DEVELOPING CONSTRAINTS USING PROTON FLUX STATES AND NUMERICALLY-DETERMINED SUB-SYSTEMS | UNIVERSITY OF DELAWARE (US) | 2009-10-15 | — | — | US | disclosed |
| EP-0095862-B1 | FERMENTATION PROCESS FOR PRODUCTION OF ALPHA-ISOPROPYLMALIC ACID | PFIZER INC. (US) | 1986-07-30 | — | — | EP | disclosed |
| EP-0095862-A1 | Fermentation process for production of alpha-isopropylmalic acid | PFIZER INC. (US) | 1983-12-07 | — | — | EP | disclosed |
| US-4407953-A | BY YARROWIA LIPOLYTICA | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| EP-0054223-A2 | Plasmid vectors for eukaryotic cells and method for selecting transfected eukaryotic cells | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-06-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12606850-B2 | Synthesis of beta-hydroxyisovalerate and methods of use | CYP51A1, CYP4Z1, CYP2U1 | ACLY 598/4885CPT2 1901/4885HSPD1 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.