SCHEMBL14101035

SCHEMBL14101035

CN(C)Cc1cnc(C(O)(c2ccccc2)C2CCCC2)s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
CHRM3 P20309 7/20 0.40
POLB P06746 1/20 0.39
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
CYP2D6 P10635 1/20 0.38
HRH1 P35367 1/20 0.38
SCN1A P35498 1/20 0.38
KMT2A Q03164 1/20 0.38
SCN2A Q99250 1/20 0.38
SCN3A Q9NY46 1/20 0.38
SLC8A1 P32418 1/20 0.37
KEAP1 Q14145 1/20 0.37
NFE2L2 Q16236 1/20 0.37
CHRM2 P08172 6/20 0.36
CHRM4 P08173 6/20 0.36
CHRM1 P11229 6/20 0.36
CHRM5 P08912 5/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4742907 0.99 CHRM3 (0.41) ALDH1A1CHRM3POLBATML3MBTL1
SCHEMBL14101285 0.83 FDPS (0.40) ALDH1A1CHRM3POLBMEN1KMT2A
SCHEMBL3227969 0.82 CHRM3 (0.41) CHRM3ATML3MBTL1MEN1LMNA
SCHEMBL14101227 0.82 CHRM3 (0.40) ALDH1A1CHRM3POLBMEN1SLC8A1
SCHEMBL14101291 0.81 ACHE (0.38) ALDH1A1CHRM3POLBCHRM2CHRM4
SCHEMBL14101197 0.81 ATM (0.43) ALDH1A1CHRM3ATML3MBTL1MEN1
SCHEMBL27795411 0.81 CHRM3 (0.40) CHRM3ATML3MBTL1MEN1LMNA
SCHEMBL1109887 0.80 CYP2D6 (0.42) ALDH1A1MEN1LMNACYP2D6KMT2A
SCHEMBL3217762 0.80 CHRM3 (0.42) CHRM3ATML3MBTL1MEN1LMNA
SCHEMBL4727213 0.80 CHRM3 (0.46) ALDH1A1CHRM3POLBATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008096093-A1 OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES ARGENTA DISCOVERY LTD. (GB) 2008-08-14 WO disclosed