Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.35 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.35 |
| ▸ | ADH5 | P11766 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723772 | 0.89 | RORC (0.42) | RORCTTRNOTUM | |
| SCHEMBL4723777 | 0.89 | RORC (0.42) | RORCTTRNOTUM | |
| SCHEMBL14101882 | 0.89 | KDM4E (0.39) | PDE4APDE4BPDE4CPDE4DNOTUM | |
| SCHEMBL14101794 | 0.88 | PTGS2 (0.42) | PDE4APDE4BPDE4CPDE4DNOTUM | |
| SCHEMBL14101706 | 0.84 | MAPT (0.38) | PDE4APDE4BPDE4CPDE4DNOTUM | |
| SCHEMBL14101736 | 0.83 | NOTUM (0.37) | PDE4APDE4BPDE4CPDE4DNOTUM | |
| SCHEMBL14101798 | 0.83 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DNOTUM | |
| SCHEMBL4724195 | 0.81 | F10 (0.42) | PDE4APDE4BPDE4CPDE4DNOTUM | |
| SCHEMBL14101895 | 0.81 | P2RX7 (0.38) | PDE4APDE4BPDE4CPDE4DNOTUM | |
| SCHEMBL4720673 | 0.81 | LCK (0.41) | RORCPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |