Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720664 | 1.00 | LCK (0.41) | LCKJAK3P2RX7RORCF10 | |
| SCHEMBL4723777 | 0.93 | RORC (0.42) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4723772 | 0.93 | RORC (0.42) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4719450 | 0.91 | P2RX7 (0.40) | LCKJAK3P2RX7RORCF10 | |
| SCHEMBL4719453 | 0.91 | P2RX7 (0.40) | LCKJAK3P2RX7RORCF10 | |
| SCHEMBL4722196 | 0.90 | HSD11B1 (0.39) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4723155 | 0.90 | PDE3B (0.39) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4722191 | 0.90 | HSD11B1 (0.39) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4723162 | 0.90 | PDE3B (0.39) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4722703 | 0.89 | P2RX7 (0.41) | P2RX7RORCPDE3BPDE3ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |