Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25333287 | 0.84 | ERN1 (0.41) | TDP1SOS1ERN1HIF1ALPAR1 | |
| SCHEMBL25333361 | 0.82 | AR (0.48) | ERN1ALDH1A1LPAR1LPAR5TRIM24 | |
| SCHEMBL25334978 | 0.79 | ALDH1A1 (0.47) | TDP1ERN1ALDH1A1KMT2ATRIM24 | |
| SCHEMBL14662079 | 0.79 | KMO (0.42) | TDP1SOS1ERN1ALDH1A1MEN1 | |
| SCHEMBL14107083 | 0.79 | HTR2A (0.37) | TDP1SOS1ALDH1A1MEN1KMT2A | |
| SCHEMBL14662307 | 0.79 | SOS1 (0.44) | TDP1SOS1ERN1ALDH1A1KMT2A | |
| SCHEMBL29428769 | 0.79 | AR (0.41) | TDP1ERN1ALDH1A1KMT2AGCK | |
| SCHEMBL25332470 | 0.77 | ALDH1A1 (0.46) | TDP1ALDH1A1KMT2AGCKEGFR | |
| SCHEMBL21855911 | 0.77 | TDP1 (0.43) | TDP1SOS1ERN1ALDH1A1EGFR | |
| SCHEMBL4973715 | 0.77 | LMNA (0.46) | TDP1ALDH1A1HTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099020-A1 | 1,1-DIOXO-1-THIA-5,10-DIAZADIBENZOCYCLOHEPTENES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008099019-A1 | 6-HYDROXY-DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008099021-A1 | DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |