Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL6764786 | 1.00 | STAT3 (0.41) | STAT3STAT1 | |
| Iodide SCHEMBL29827551 | 1.00 | STAT3 (0.41) | STAT3STAT1 | |
| Iodide SCHEMBL11328134 | 0.97 | STAT3 (0.40) | STAT3STAT1 | |
| Iodide SCHEMBL1859209 | 0.97 | STAT3 (0.40) | STAT3STAT1 | |
| Iodide SCHEMBL11341933 | 0.97 | STAT3 (0.40) | STAT3STAT1 | |
| Iodide SCHEMBL11328136 | 0.97 | STAT3 (0.40) | STAT3STAT1 | |
| SCHEMBL29430977 | 0.97 | STAT3 (0.42) | STAT3STAT1 | |
| SCHEMBL9430673 | 0.97 | STAT3 (0.42) | STAT3STAT1 | |
| SCHEMBL30821407 | 0.97 | STAT3 (0.42) | STAT3STAT1 | |
| SCHEMBL6517023 | 0.97 | STAT3 (0.42) | STAT3STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101613353-A | The method of a kind of synthetic four (4-dimethylaminophenyl) porphyrins and derivative thereof | UNIV FUDAN | 2009-12-30 | — | — | CN | claimed |
| US-9289434-B2 | Substituted porphyrins | AEOLUS SCIENCES, INC. (US) | 2016-03-22 | — | — | US | disclosed |
| US-20150231150-A1 | SUBSTITUTED PORPHYRINS | AEOLUS PHARMACEUTICALS INC. | 2015-08-20 | — | — | US | disclosed |
| US-8946202-B2 | Substituted porphyrins | AEOLUS SCIENCES, INC. (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140011794-A1 | SUBSTITUTED PORPHYRINS | Aeouls Sciences, Inc. (US) | 2014-01-09 | — | — | US | disclosed |
| US-8546562-B2 | Substituted porphyrins | DUKE UNIVERSITY | 2013-10-01 | — | — | US | disclosed |
| US-20120214780-A1 | SUBSTITUTED PORPHYRINS | AEOLUS SCIENCES, INC. (US) | 2012-08-23 | — | — | US | disclosed |
| US-8217026-B2 | Substituted porphyrins | AEOLUS SCIENCES, INC. (US) | 2012-07-10 | — | — | US | disclosed |
| CN-101613353-B | Method for synthesizing tetra (4-dimethylaminophenyl) porphyrin and derivatives thereof | UNIV FUDAN | 2012-05-23 | — | — | CN | disclosed |
| US-20110065679-A1 | Substituted Porphyrins | AEOLUS PHARMACEUTICALS, INC. (US) | 2011-03-17 | — | — | US | disclosed |
| US-20040023941-A1 | Modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and | NATIONAL JEWISH MEDICAL AND RESEARCH CENTER | 2004-02-05 | — | — | US | disclosed |
| CN-1450066-A | Porphyrin derivate with macrosubstituent, preparation process thereof and use as small molecule antioxidant | GONG XIANCHANG (CN) | 2003-10-22 | — | — | CN | disclosed |
| US-6544975-B1 | Mimetics that inhibit lipid peroxidation; for use in the treatment of diseases or disorders mediated by oxidative stress, such as asthma, inflammatory bowel disease, arthritis and vasculitis. | NATIONAL JEWISH MEDICAL AND RESEARCH CENTER | 2003-04-08 | — | — | US | disclosed |
| EP-1155019-A4 | SUBSTITUTED PORPHYRINS | NAT JEWISH MED & RES CENTER (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-1155019-A1 | SUBSTITUTED PORPHYRINS | National Jewish Medical and Research Center (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000043395-A1 | SUBSTITUTED PORPHYRINS | NATIONAL JEWISH MEDICAL AND RESEARCH CENTER (US) | 2000-07-27 | — | — | WO | disclosed |
| US-5236914-A | Antitumor agents, viricides | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1993-08-17 | — | — | US | disclosed |
| US-4256597-A | DETERGENT AND PHOTOINITIATOR COMPRISING A PORPHINE OR MONO, DI, OR TRIAZO PORPHINE, OR PHTHALOCYANINE COMPOUND; WATER SOLUBILITY; STAIN REMOVAL | THE PROCTER & GAMBLE COMPANY (US) | 1981-03-17 | — | — | US | disclosed |
| US-4255273-A | COMPRISING A WATER-SOLUBLE PHOTOACTIVATOR AND A CATIONIC SUBSTANCE | THE PROCTER & GAMBLE COMPANY (US) | 1981-03-10 | — | — | US | disclosed |
| EP-0003149-A2 | Composition containing a photoactivator for improved washing and bleaching of fabrics | THE PROCTER & GAMBLE COMPANY (US) | 1979-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214780-A1 | SUBSTITUTED PORPHYRINS | PPOX, GPX4, PRDX5 | STAT3 892/4885STAT1 1589/4885 |
| US-20150231150-A1 | SUBSTITUTED PORPHYRINS | PPOX, GPX4, PRDX5 | STAT3 892/4885STAT1 1589/4885 |
| US-20110065679-A1 | Substituted Porphyrins | PPOX, GPX4, PRDX5 | STAT3 892/4885STAT1 1589/4885 |
| US-20040023941-A1 | Modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and | TXN2, PRDX5, GPX4 | STAT3 690/4885STAT1 941/4885 |
| US-20140011794-A1 | SUBSTITUTED PORPHYRINS | PPOX, GPX4, PRDX5 | STAT3 892/4885STAT1 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.