Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14104083 | 0.93 | L3MBTL1 (0.39) | TRPA1MAPTMAPK1L3MBTL1MET | |
| SCHEMBL14103816 | 0.93 | MTOR (0.40) | TRPA1MAPTMAPK1L3MBTL1MET | |
| SCHEMBL14103885 | 0.93 | TRPA1 (0.38) | TRPA1MAPTMAPK1L3MBTL1MET | |
| SCHEMBL14103813 | 0.93 | PIK3CA (0.40) | TRPA1MAPTMAPK1L3MBTL1MET | |
| SCHEMBL14103797 | 0.92 | HTT (0.47) | TRPA1MAPTMAPK1L3MBTL1ABCG2 | |
| SCHEMBL14103756 | 0.92 | TRPA1 (0.41) | TRPA1MAPTMAPK1L3MBTL1MET | |
| SCHEMBL4574977 | 0.92 | MAPK1 (0.51) | TRPA1MAPTMAPK1L3MBTL1MET | |
| SCHEMBL14103794 | 0.91 | MAPK1 (0.40) | MAPTMAPK1METKITFLT3 | |
| SCHEMBL14104442 | 0.91 | MET (0.38) | TRPA1MAPTMAPK1L3MBTL1MET | |
| SCHEMBL14104186 | 0.90 | MET (0.39) | TRPA1MAPK1L3MBTL1METPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |