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SCHEMBL1411935

SCHEMBL1411935

CC(=O)n1c(=O)c(C)cn([C@H]2CC(O)[C@@H](CO)O2)c1=O

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TK1 P04183 3/20 0.47
▸ LMNA P02545 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ ADRB1 P08588 1/20 0.47
▸ DNMT1 P26358 1/20 0.47
▸ TK2 O00142 1/20 0.47
▸ ALOX12 P18054 1/20 0.45
▸ ADRA1A P35348 1/20 0.45
▸ CYP1A2 P05177 1/20 0.43
▸ CYP3A4 P08684 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ BLM P54132 1/20 0.43
▸ PMP22 Q01453 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ PIM1 P11309 1/20 0.42
▸ CSNK2A2 P19784 1/20 0.42
▸ CSNK2B P67870 1/20 0.42
▸ CSNK2A1 P68400 1/20 0.42
▸ CSNK2A3 Q8NEV1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14855864 1.00 TK1 (0.47) TK1LMNASMN1; SMN2ADRB1DNMT1
SCHEMBL10580076 0.89 TK1 (0.39) TK1
SCHEMBL15216129 0.87 LMNA (0.45) TK1LMNASMN1; SMN2ADRB1DNMT1
SCHEMBL1271665 0.87 TK1 (0.46) TK1LMNASMN1; SMN2ADRB1DNMT1
SCHEMBL7607469 0.86 TK1 (0.44) TK1LMNASMN1; SMN2ADRB1DNMT1
SCHEMBL537189 0.85 RNASE1 (0.48) TK1LMNASMN1; SMN2TK2CYP1A2
SCHEMBL8581198 0.85 POLB (0.41) TK1
SCHEMBL21563929 0.85 TK1 (0.43) TK1LMNASMN1; SMN2TK2
SCHEMBL21563855 0.85 RNASE1 (0.48) TK1LMNASMN1; SMN2TK2CYP1A2
SCHEMBL9443821 0.85 RNASE1 (0.48) TK1LMNASMN1; SMN2TK2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2580198-A1 THERMOLABILE 2 - (N- 2 - PYRIDIYL - N- BENZYL) - AMINOETHYLOXYCARBONYL DERIVATIVES AS HYDROXYL FUNCTION PROTECTING AGENTS Instytut Chemii Bioorganicznej Polskiej Akademii Nauk (PL) 2013-04-17 — — EP disclosed
WO-2011155855-A1 THERMOLABILE 2 - (N- 2 - PYRIDIYL - N- BENZYL) - AMINOETHYLOXYCARBONYL DERIVATIVES AS HYDROXYL FUNCTION PROTECTING AGENTS INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK (PL) 2011-12-15 — — WO disclosed
EP-2294076-A1 CHEMICALLY MODIFIED NUCLEOSIDE 5'-TRIPHOSPHATES FOR THERMALLY INITIATED AMPLIFICATION OF NUCLEIC ACID TriLink BioTechnologies (US) 2011-03-16 — — EP disclosed
WO-2009151921-A1 CHEMICALLY MODIFIED NUCLEOSIDE 5'-TRIPHOSPHATES FOR THERMALLY INITIATED AMPLIFICATION OF NUCLEIC ACID TRILINK BIOTECHNOLOGIES (US) 2009-12-17 — — WO disclosed
EP-0766688-A4 SYNTHESIS OF OLIGONUCLEOTIDES ISIS PHARMACEUTICALS INC (US) 1998-12-30 — — EP disclosed
EP-0766688-A1 SYNTHESIS OF OLIGONUCLEOTIDES ISIS PHARMACEUTICALS, INC. (US) 1997-04-09 — — EP disclosed
EP-0586520-A4 BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS ISIS PHARMACEUTICALS INC (US) 1996-01-10 — — EP disclosed
WO-1995032980-A1 SYNTHESIS OF OLIGONUCLEOTIDES ISIS PHARMACEUTICALS, INC. (US) 1995-12-07 — — WO disclosed
EP-0586520-A1 BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS ISIS PHARMACEUTICALS, INC. (US) 1994-03-16 — — EP disclosed
WO-1992020823-A1 BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS ISIS PHARMACEUTICALS, INC. (US) 1992-11-26 — — WO disclosed
EP-0358657-A1 POLY(DEOXYRIBONUCLEOTIDES), PHARMACEUTICAL COMPOSITIONS, USE AND PREPARATION OF THE POLY(DEOXYRIBONUCLEOTIDES). UNIV EINDHOVEN TECH (NL) 1990-03-21 — — EP disclosed
WO-1988007542-A1 POLY(DEOXYRIBONUCLEOTIDES), PHARMACEUTICAL COMPOSITIONS, USE AND PREPARATION OF THE POLY(DEOXYRIBONUCLEOTIDES) TECHNISCHE UNIVERSITEIT EINDHOVEN (NL) 1988-10-06 — — WO disclosed