Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Adenine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AHCY | P23526 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL385841 | 0.91 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL9621204 | 0.89 | GDA (0.46) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL1871837 | 0.89 | PI4KA (0.44) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL3413247 | 0.87 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL3416954 | 0.87 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL8110 | 0.87 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL16485900 | 0.86 | PI4KA (0.37) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL16485906 | 0.86 | PI4KA (0.37) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL5663794 | 0.86 | CYP1A2 (0.43) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL9952923 | 0.85 | MTAP (0.39) | PI4KAPI4K2BPI4K2API4KBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119039583-B | Side-chain base biodegradable polyester amide with stereocomplex crystallization performance and enzymatic preparation method thereof | 浙江农林大学 | 2025-03-11 | — | — | CN | claimed |
| CN-119039583-A | Side-chain base biodegradable polyester amide with stereocomplex crystallization performance and enzymatic preparation method thereof | 浙江农林大学 | 2024-11-29 | — | — | CN | claimed |
| CN-119039583-B | Side-chain base biodegradable polyester amide with stereocomplex crystallization performance and enzymatic preparation method thereof | 浙江农林大学 | 2025-03-11 | — | — | CN | disclosed |
| CN-119039583-A | Side-chain base biodegradable polyester amide with stereocomplex crystallization performance and enzymatic preparation method thereof | 浙江农林大学 | 2024-11-29 | — | — | CN | disclosed |
| US-10093674-B2 | Supramolecular nanofibers and hydrogels based on nucleic acids functionalized with nucleobases | BRANDEIS UNIVERSITY (US) | 2018-10-09 | — | — | US | disclosed |
| US-20180100036-A1 | CLICK NUCLEIC ACID POLYMERS AND METHODS OF USE | UNIV COLORADO REGENTS (US) | 2018-04-12 | — | — | US | disclosed |
| US-20140148410-A1 | Supramolecular Nanofibers and Hydrogels Based on Nucleic Acids Functionalized with Nucleobases | BRANDEIS UNIVERSITY (US) | 2014-05-29 | — | — | US | disclosed |
| WO-2012166705-A2 | SUPRAMOLECULAR NANOFIBERS AND HYDROGELS BASED ON AMINO ACID-NUCLEOBASE-GLYCOSIDE CONJUGATES | BRANDEIS UNIVERSITY (US) | 2012-12-06 | — | — | WO | disclosed |
| WO-2012166706-A2 | SUPRAMOLECULAR NANOFIBERS AND HYDROGELS BASED ON OLIGOPEPTIDES FUNCTIONALIZED WITH NUCLEOBASES | BRANDEIS UNIVERSITY (US) | 2012-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148410-A1 | Supramolecular Nanofibers and Hydrogels Based on Nucleic Acids Functionalized with Nucleobases | PHAX, PCNA, RBM28 | PI4KA 3415/4885PI4K2B 3725/4885PI4K2A 3501/4885 |
| US-10093674-B2 | Supramolecular nanofibers and hydrogels based on nucleic acids functionalized with nucleobases | PHAX, PCNA, RBM28 | PI4KA 3415/4885PI4K2B 3725/4885PI4K2A 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.