Adenine

Adenine

SCHEMBL385841

Nc1ncnc2[nH]cnc12.OO

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PI4KA P42356 5/20 0.45
PI4K2B Q8TCG2 5/20 0.45
PI4K2A Q9BTU6 5/20 0.45
PI4KB Q9UBF8 5/20 0.45
XDH P47989 2/20 0.45
LRRK2 Q5S007 2/20 0.45
LMNA P02545 1/20 0.45
DRD3 P35462 1/20 0.45
ADORA2A P29274 3/20 0.38
ADORA1 P30542 3/20 0.38
RET P07949 1/20 0.36
ERAP1 Q9NZ08 1/20 0.36
GDA Q9Y2T3 1/20 0.36
AHCY P23526 1/20 0.33
EGFR P00533 1/20 0.33
PIK3CG P48736 2/20 0.33
ADORA2B P29275 1/20 0.33
PNP P00491 1/20 0.32
MAP4K4 O95819 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adenine SCHEMBL3414603 0.96 PI4KA (0.48) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL3416954 0.96 PI4KA (0.48) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL3413247 0.96 PI4KA (0.48) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL8110 0.96 PI4KA (0.48) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL1871837 0.94 PI4KA (0.44) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL2895675 0.93 PI4KA (0.47) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL1370888 0.93 PI4KA (0.47) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL20485928 0.93 PI4KA (0.47) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL10868999 0.93 PI4KA (0.47) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL11798390 0.93 PI4KA (0.50) PI4KAPI4K2BPI4K2API4KBXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150231177-A1 Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications VIRGINIA COMMONWEALTH UNIVERSITY (US) 2015-08-20 US claimed
US-20120207793-A1 Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications VIRGINIA COMMONWEALTH UNIVERSITY 2012-08-16 US claimed
EP-2252333-A2 GAS BASED WOUND AND TISSUE THERAPEUTICS Oxygen Biotherapeutics, Inc. (US) 2010-11-24 EP claimed
WO-2009102487-A2 GAS BASED WOUND AND TISSUE THERAPEUTICS OXYGEN BIOTHERAPEUTICS, INC. (US) 2009-08-20 WO claimed
US-20090169630-A1 Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications VIRGINIA COMMONWEALTH UNIVERSITY 2009-07-02 US claimed
EP-2024287-A1 METHODS AND COMPOSITIONS FOR CONTROLLED AND SUSTAINED PRODUCTION AND DELIVERY OF PEROXIDES Virginia Commonwealth University (US) 2009-02-18 EP claimed
WO-2007134304-A1 METHODS AND COMPOSITIONS FOR CONTROLLED AND SUSTAINED PRODUCTION AND DELIVERY OF PEROXIDES VIRGINIA COMMONWEALTH UNIVERSITY (US) 2007-11-22 WO claimed
US-20150231177-A1 Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications VIRGINIA COMMONWEALTH UNIVERSITY (US) 2015-08-20 US disclosed
US-20130289471-A1 GAS BASED WOUND AND TISSUE THERAPEUTICS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2013-10-31 US disclosed
US-20120207793-A1 Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications VIRGINIA COMMONWEALTH UNIVERSITY 2012-08-16 US disclosed
US-20120184898-A1 GAS BASED WOUND AND TISSUE THERAPEUTICS TENAX THERAPEUTICS, INC 2012-07-19 US disclosed
US-8101117-B2 Controlled gas pore formers in extruded ware CORNING, INCORPORATED (US) 2012-01-24 US disclosed
EP-2252333-A2 GAS BASED WOUND AND TISSUE THERAPEUTICS Oxygen Biotherapeutics, Inc. (US) 2010-11-24 EP disclosed
US-20090298667-A1 Controlled Gas Pore Formers in Extruded Ware CORNING INCORPORATED 2009-12-03 US disclosed
WO-2009102487-A2 GAS BASED WOUND AND TISSUE THERAPEUTICS OXYGEN BIOTHERAPEUTICS, INC. (US) 2009-08-20 WO disclosed
US-20090202617-A1 Gas based wound and tissue therapeutics TENAX THERAPEUTICS, INC 2009-08-13 US disclosed
US-20090169630-A1 Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications VIRGINIA COMMONWEALTH UNIVERSITY 2009-07-02 US disclosed
EP-2024287-A1 METHODS AND COMPOSITIONS FOR CONTROLLED AND SUSTAINED PRODUCTION AND DELIVERY OF PEROXIDES Virginia Commonwealth University (US) 2009-02-18 EP disclosed
WO-2009006586-A2 SELF-CONTAINED OXYGEN GENERATING AND BREATHING SYSTEMS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2009-01-08 WO disclosed
WO-2007134304-A1 METHODS AND COMPOSITIONS FOR CONTROLLED AND SUSTAINED PRODUCTION AND DELIVERY OF PEROXIDES VIRGINIA COMMONWEALTH UNIVERSITY (US) 2007-11-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090202617-A1 Gas based wound and tissue therapeutics PGF, FGF2, FGF1 PI4KA 3364/4885PI4K2B 3323/4885PI4K2A 3689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.