Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3030225 | 0.84 | LEF1 (0.60) | LEF1MMP13MAOAMAOBKDM4E | |
| SCHEMBL13311254 | 0.83 | LEF1 (0.59) | LEF1MMP13MAOAMAOBKDM4E | |
| SCHEMBL6617416 | 0.83 | LEF1 (0.74) | LEF1MMP13KDM4ENPC1RAB9A | |
| SCHEMBL29830077 | 0.80 | LEF1 (0.67) | LEF1MMP13MAOAMAOBKDM4E | |
| SCHEMBL29783677 | 0.80 | FLT3 (0.59) | LEF1PDGFRBPDGFRAFLT3 | |
| SCHEMBL20742974 | 0.80 | FLT3 (0.59) | LEF1PDGFRBPDGFRAFLT3 | |
| SCHEMBL6619949 | 0.79 | LEF1 (0.81) | LEF1MMP13KDM4ENPC1RAB9A | |
| SCHEMBL3027522 | 0.79 | MMP13 (0.72) | LEF1HRH3MMP13MAOAKDM4E | |
| SCHEMBL16756055 | 0.79 | MAOB (0.58) | LEF1MMP13MAOAMAOBNPC1 | |
| SCHEMBL17055701 | 0.78 | LEF1 (0.53) | LEF1MMP13MAOAMAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008083312-A2 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2008-07-10 | — | — | WO | disclosed |