Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543631 | 0.89 | ALDH1A1 (0.50) | KDM4EPTGDR2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL14148599 | 0.85 | ADORA1 (0.53) | KDM4EPTGDR2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL14148613 | 0.84 | ADORA2A (0.55) | KDM4EPTGDR2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL14148757 | 0.83 | PTGDR2 (0.57) | KDM4EPTGDR2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL11652829 | 0.83 | ALOX5 (0.54) | KDM4EPTGDR2ALDH1A1LMNAGAA | |
| SCHEMBL544858 | 0.81 | CDC7 (0.61) | KDM4EPTGDR2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL11462189 | 0.81 | KDM4E (0.58) | KDM4EPTGDR2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL11460695 | 0.81 | KDM4E (0.58) | KDM4EPTGDR2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL11284205 | 0.81 | KDM4E (0.58) | KDM4EPTGDR2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL11456645 | 0.80 | APEX1 (0.72) | KDM4EPTGDR2ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |