Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543631 | 0.89 | ALDH1A1 (0.50) | PTGDR2ADORA1ADORA2ARARARARB | |
| SCHEMBL11652829 | 0.83 | ALOX5 (0.54) | PTGDR2ALOX5ADORA1ADORA2ADPP4 | |
| SCHEMBL14148598 | 0.83 | KDM4E (0.57) | PTGDR2ADORA1ADORA2ADPP4RARA | |
| SCHEMBL14148616 | 0.83 | DPP4 (0.50) | PTGDR2ADORA1ADORA2ADPP4CDC7 | |
| SCHEMBL11287147 | 0.81 | PTGS2 (0.74) | PTGDR2ALOX5PTGS2KDM4EALDH1A1 | |
| SCHEMBL544858 | 0.81 | CDC7 (0.61) | PTGDR2ADORA1ADORA2AKDM4EPOLB | |
| SCHEMBL14148755 | 0.80 | PTGDR2 (0.60) | PTGDR2ALOX5ADORA1ADORA2ADPP4 | |
| SCHEMBL14148648 | 0.80 | PTGDR2 (0.60) | PTGDR2ALOX5ADORA1ADORA2ADPP4 | |
| SCHEMBL14148746 | 0.78 | MAPT (0.51) | PTGDR2PTGS2APPKDM4ERAB9A | |
| SCHEMBL29272745 | 0.77 | MYC (0.57) | ALOX5ADORA1ADORA2AAPPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |