Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14148755 | 0.80 | PTGDR2 (0.60) | KDM4EALDH1A1HSD17B10MAPTTP53 | |
| SCHEMBL14148648 | 0.80 | PTGDR2 (0.60) | KDM4EALDH1A1HSD17B10MAPTTP53 | |
| SCHEMBL10120491 | 0.77 | KDM4E (0.61) | GUSBKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL19626668 | 0.75 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10MAPTCYP3A4 | |
| SCHEMBL15075737 | 0.75 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10MAPTCYP3A4 | |
| SCHEMBL14148673 | 0.74 | GUSB (0.47) | GUSBKDM4EALDH1A1MAPTTP53 | |
| SCHEMBL9829979 | 0.73 | ALOX5 (0.62) | KDM4EALDH1A1HSD17B10MAPTTP53 | |
| SCHEMBL2092168 | 0.72 | AHR (0.61) | GUSBALDH1A1TP53NPC1RAB9A | |
| SCHEMBL19625510 | 0.71 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10MAPTCYP3A4 | |
| SCHEMBL19650376 | 0.71 | MYC (0.60) | KDM4EALDH1A1HSD17B10MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |