Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14148671 | 0.84 | PTGDR2 (0.52) | CREBBPPTGDR2MAPTLMNAALOX5 | |
| SCHEMBL14148669 | 0.74 | GUSB (0.53) | GUSBPTGDR2MAPTTP53ALOX5 | |
| SCHEMBL14148610 | 0.71 | PTGDR2 (0.48) | PTGDR2MAPTLMNATP53ALOX5 | |
| SCHEMBL14148743 | 0.65 | ALDH1A1 (0.50) | MAPTKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL14148618 | 0.65 | PTGS2 (0.42) | PTGDR2MAPTLMNATP53KDM4E | |
| SCHEMBL14148619 | 0.65 | ADORA2A (0.42) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL2092168 | 0.64 | AHR (0.61) | GUSBDYRK1ATP53NPC1ALDH1A1 | |
| SCHEMBL10120491 | 0.63 | KDM4E (0.61) | GUSBMAPTLMNATP53KDM4E | |
| SCHEMBL23456289 | 0.63 | GAA (0.48) | CREBBPMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL11275235 | 0.62 | ALOX5 (0.74) | PTGDR2MAPTLMNAALOX5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |