Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14148755 | 1.00 | PTGDR2 (0.60) | PTGDR2ADORA2AADORA1ADORA3ALOX5 | |
| SCHEMBL14148594 | 0.85 | RAB9A (0.58) | PTGDR2ADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL543631 | 0.85 | ALDH1A1 (0.50) | PTGDR2ADORA2AADORA1ADORA3KDM4E | |
| SCHEMBL11452752 | 0.84 | ALOX5 (0.73) | PTGDR2ADORA2AADORA1ADORA3ALOX5 | |
| SCHEMBL11274476 | 0.84 | ALOX5 (0.73) | PTGDR2ADORA2AADORA1ADORA3ALOX5 | |
| SCHEMBL11652829 | 0.83 | ALOX5 (0.54) | PTGDR2ADORA2AADORA1ADORA3ALOX5 | |
| SCHEMBL14148747 | 0.81 | ADORA1 (0.59) | PTGDR2ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL14148669 | 0.80 | GUSB (0.53) | PTGDR2ADORA2AADORA1ADORA3ALOX5 | |
| SCHEMBL14148757 | 0.80 | PTGDR2 (0.57) | PTGDR2ADORA2AADORA1ALOX5KDM4E | |
| SCHEMBL14148598 | 0.80 | KDM4E (0.57) | PTGDR2ADORA2AADORA1ADORA3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |