Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 12/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.43 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10624841 | 0.79 | LMNA (0.79) | LMNAALDH1A1NPSR1PLA2G2ASMN1; SMN2 | |
| SCHEMBL4148079 | 0.72 | LMNA (0.52) | LMNAALDH1A1NPSR1PLA2G2A | |
| SCHEMBL27594850 | 0.70 | PLA2G2A (0.57) | LMNAALDH1A1NPSR1PLA2G2APLA2G10 | |
| SCHEMBL29953446 | 0.69 | VDR (0.79) | LMNAALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL4881337 | 0.68 | ALDH1A1 (0.69) | LMNAALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL8717608 | 0.68 | LMNA (0.59) | LMNAALDH1A1NPSR1PLA2G2ASMN1; SMN2 | |
| SCHEMBL3406142 | 0.68 | KMT2A (0.65) | LMNAALDH1A1NPSR1PLA2G2APLA2G1B | |
| SCHEMBL28787856 | 0.67 | PLA2G2A (0.53) | PLA2G2A | |
| SCHEMBL23790932 | 0.67 | MEN1 (0.35) | LMNAALDH1A1 | |
| SCHEMBL3389070 | 0.66 | LMNA (0.74) | LMNAALDH1A1NPSR1PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950200-A1 | [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid methyl ester as sPLA2 inhibitor | ELI LILLY AND COMPANY (US) | 2008-07-30 | — | — | EP | disclosed |