Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073601 | 0.79 | AGTR1 (0.46) | AGTR1AGTR2PPARG | |
| SCHEMBL4556467 | 0.78 | CYP11B1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL9308629 | 0.78 | HDAC1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL594508 | 0.77 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL4935797 | 0.77 | AGTR1 (0.44) | AGTR1AGTR2PPARG | |
| SCHEMBL4250985 | 0.77 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL3630525 | 0.76 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL8833764 | 0.76 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL8833882 | 0.75 | RAB9A (0.40) | — | |
| SCHEMBL8543595 | 0.75 | CASP3 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291076-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009140111-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2009-11-19 | — | — | WO | disclosed |