Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27411710 | 0.88 | KMT2A (0.44) | HDAC1HDAC8HDAC6AGTR1KMT2A | |
| SCHEMBL9449474 | 0.82 | AGTR1 (0.41) | AGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL9346770 | 0.81 | AGTR1 (0.41) | AGTR1AGTR2 | |
| SCHEMBL7284844 | 0.80 | AGTR1 (0.43) | AGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL9350439 | 0.79 | AGTR1 (0.44) | AGTR1AGTR2 | |
| SCHEMBL684181 | 0.79 | AGTR1 (0.50) | AGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL9350392 | 0.78 | PPARG (0.39) | AGTR1 | |
| SCHEMBL1415178 | 0.78 | AGTR1 (0.41) | AGTR1AGTR2 | |
| SCHEMBL8543595 | 0.77 | CASP3 (0.46) | HDAC1HDAC8HDAC6 | |
| SCHEMBL588365 | 0.77 | AGTR1 (0.41) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371226-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-12-06 | — | — | US | claimed |
| JP-6025174-A | — | — | None | — | — | JP | disclosed |
| JP-H0625174-A | 2-OXOQUINOLINE DERIVATIVE | MERCK PATENT GMBH | 1994-02-01 | — | — | JP | disclosed |