Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.70 |
| ▸ | FYN | P06241 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14153055 | 0.79 | TAAR1 (0.55) | HPGDSCHEK2MAP4K4CYP11B1KDM1A | |
| SCHEMBL31137909 | 0.78 | CYP11B2 (0.46) | HPGDSIDO1CHEK2MAP4K4CYP11B1 | |
| SCHEMBL1543156 | 0.78 | HPGDS (0.76) | HPGDSFYNIDO1LDHACHEK2 | |
| SCHEMBL2767722 | 0.77 | HPGDS (0.74) | HPGDSFYNIDO1LDHACHEK2 | |
| SCHEMBL14153221 | 0.74 | BRAF (0.45) | HPGDSIDO1LDHACYP11B1KDM1A | |
| SCHEMBL14153034 | 0.74 | MAP4K4 (0.45) | HPGDSFYNCHEK2MAP4K4HSD17B1 | |
| SCHEMBL2318238 | 0.73 | HPGDS (0.60) | HPGDSFYNIDO1LDHAMAP4K4 | |
| SCHEMBL15913469 | 0.73 | GRM5 (0.55) | HPGDS | |
| SCHEMBL14061548 | 0.73 | GRM5 (0.55) | HPGDS | |
| SCHEMBL102455 | 0.72 | PARP1 (0.59) | KDM1AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162635-A1 | METABOTROPIC GLUTAMATE RECEPTORS 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2012-11-29 | — | — | WO | disclosed |