Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355076 | 0.79 | HPGDS (0.56) | LDHANPC1RXFP1MAPK14CYP11B1 | |
| SCHEMBL5473610 | 0.78 | BRAF (0.59) | BRAFMAPK3MAPK1ALOX5KDM1A | |
| SCHEMBL14153247 | 0.78 | BRAF (0.59) | BRAFMAPK3MAPK1ALOX5KDM1A | |
| SCHEMBL14153528 | 0.77 | P4HTM (0.55) | MAPK1KDM1ANPC1HPGDSGAA | |
| SCHEMBL14433318 | 0.75 | APP (0.36) | KDM1ANPC1GAARAB9A | |
| SCHEMBL12572567 | 0.74 | RAB9A (0.36) | BRAFMAPK3MAPK1LDHAKDM1A | |
| SCHEMBL14153035 | 0.74 | HPGDS (0.70) | LDHAKDM1ANPC1RXFP1CYP11B1 | |
| SCHEMBL5734988 | 0.74 | LDHA (0.73) | LDHANPC1RXFP1GAARAB9A | |
| SCHEMBL641911 | 0.73 | KDM1A (0.53) | BRAFMAPK3MAPK1ALOX5KDM1A | |
| SCHEMBL282989 | 0.73 | KDM1A (0.53) | BRAFMAPK3MAPK1ALOX5KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162635-A1 | METABOTROPIC GLUTAMATE RECEPTORS 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2012-11-29 | — | — | WO | disclosed |