Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132803 | 0.79 | ALDH1A1 (0.52) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL1408706 | 0.76 | ALDH1A1 (0.48) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL4685687 | 0.76 | ALDH1A1 (0.48) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL8473466 | 0.74 | ALOX12 (0.41) | SMN1; SMN2RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL3899031 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL14156321 | 0.73 | NPC1 (0.54) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL14156335 | 0.73 | CYP1A2 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL4472565 | 0.72 | ALDH1A1 (0.44) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL12683737 | 0.72 | ALDH1A1 (0.49) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL21798510 | 0.70 | NOTUM (0.50) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7381734-B2 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2008-06-03 | — | — | US | disclosed |
| US-7157585-B2 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2007-01-02 | — | — | US | disclosed |