Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.79 |
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616180 | 0.88 | HSD11B1 (1.00) | HSD11B1RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL15314545 | 0.82 | HSD11B1 (0.68) | HSD11B1RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL14159648 | 0.80 | HSD11B1 (0.75) | HSD11B1 | |
| SCHEMBL3623669 | 0.71 | HSD11B1 (0.84) | HSD11B1HTTALDH1A1MAPTTSHR | |
| SCHEMBL3621424 | 0.70 | HSD11B1 (1.00) | HSD11B1RAB9ANPC1ALDH1A1TSHR | |
| SCHEMBL3621674 | 0.70 | HSD11B1 (0.73) | HSD11B1SMN1; SMN2HTTMAPTTSHR | |
| SCHEMBL3620712 | 0.70 | HSD11B1 (0.64) | HSD11B1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14183885 | 0.68 | RAB9A (0.40) | HSD11B1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3612338 | 0.66 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL6313243 | 0.62 | HPGD (0.59) | RAB9ANPC1SMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1935420-A1 | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors | Merck Sante (FR) | 2008-06-25 | — | — | EP | disclosed |