Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 9/20 | 0.44 |
| ▸ | RAB9A | P51151 | 9/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BMP1 | P13497 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14159668 | 0.82 | HSD11B1 (0.79) | HSD11B1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL3616180 | 0.81 | HSD11B1 (1.00) | HSD11B1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL3623669 | 0.64 | HSD11B1 (0.84) | HSD11B1HTTALDH1A1TSHR | |
| SCHEMBL3621674 | 0.64 | HSD11B1 (0.73) | HSD11B1SMN1; SMN2HTTTSHRMAPK1 | |
| SCHEMBL3620712 | 0.63 | HSD11B1 (0.64) | HSD11B1NPC1RAB9ASMN1; SMN2BMP1 | |
| SCHEMBL3612338 | 0.60 | HSD11B1 (1.00) | HSD11B1EPHX2 | |
| SCHEMBL6313243 | 0.60 | HPGD (0.59) | NPC1RAB9ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL3518102 | 0.60 | HSD11B1 (0.49) | HSD11B1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL4034138 | 0.60 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL29463848 | 0.59 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2HTTBMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094263-B1 | 2-ADAMANTYL-BUTYRAMIDE DERIVATIVES AS SELECTIVE 11 BETA-HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-10-16 | — | — | EP | disclosed |