Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.56 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13503640 | 0.86 | ENPP2 (0.56) | ENPP2CHRM3CHRM1CHRM5CHRM2 | |
| SCHEMBL13681468 | 0.79 | CHRM3 (0.65) | CHRM3CHRM1CHRM2SIGMAR1OPRM1 | |
| SCHEMBL7110222 | 0.77 | ENPP2 (0.64) | ENPP2CHRM3CHRM1CHRM5CHRM2 | |
| SCHEMBL1058888 | 0.77 | SIGMAR1 (0.60) | ENPP2CHRM3CHRM1CHRM5CHRM2 | |
| SCHEMBL13681469 | 0.76 | OPRD1 (0.49) | CHRM3CHRM1CHRM2SIGMAR1OPRM1 | |
| SCHEMBL7110221 | 0.76 | ENPP2 (0.62) | ENPP2CHRM3CHRM1CHRM5CHRM2 | |
| SCHEMBL14409748 | 0.76 | CCNK (0.56) | CCNKCCNA2CDK2CDK12SIGMAR1 | |
| SCHEMBL4805754 | 0.75 | SIGMAR1 (0.55) | ENPP2CHRM3CHRM1CHRM5CHRM2 | |
| SCHEMBL4803972 | 0.75 | SIGMAR1 (0.55) | ENPP2CHRM3CHRM1CHRM5CHRM2 | |
| SCHEMBL4803965 | 0.75 | SIGMAR1 (0.55) | ENPP2CHRM3CHRM1CHRM5CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146572-A1 | N-SULFONYLUREA APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2008-06-19 | — | — | US | disclosed |
| US-7358251-B2 | N-sulfonylurea apoptosis promoters | ABBOTT LABORATORIES (US) | 2008-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146572-A1 | N-SULFONYLUREA APOPTOSIS PROMOTERS | BAX, BCL2, BAD | ENPP2 2114/4885CHRM3 4504/4885CHRM1 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.