Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7110221 | 0.89 | ENPP2 (0.62) | ENPP2KDM4EMEN1NPC1MITF | |
| SCHEMBL7659522 | 0.84 | ENPP2 (0.60) | ENPP2KDM4EMEN1NPC1MITF | |
| SCHEMBL10891234 | 0.78 | ALDH1A1 (0.62) | ENPP2KDM4EMEN1NPC1MITF | |
| SCHEMBL7105658 | 0.77 | OPRK1 (0.45) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL14174341 | 0.77 | ENPP2 (0.59) | ENPP2ALDH1A1CHRM3CHRM5CHRM1 | |
| SCHEMBL7181893 | 0.76 | ALDH1A1 (0.60) | ENPP2KDM4EMEN1NPC1MITF | |
| SCHEMBL21872794 | 0.76 | ENPP2 (0.60) | ENPP2MEN1ALDH1A1KMT2ACHRM3 | |
| SCHEMBL13503640 | 0.74 | ENPP2 (0.56) | ENPP2ALDH1A1CHRM3CHRM5CHRM1 | |
| SCHEMBL7116418 | 0.74 | KDM4E (0.48) | ENPP2KDM4EMEN1NPC1MITF | |
| SCHEMBL29009687 | 0.74 | ENPP2 (0.58) | ENPP2KDM4EMEN1NPC1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1013639-B1 | Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit | HOFFMANN LA ROCHE (CH) | 2003-10-01 | — | — | EP | disclosed |
| EP-1013639-A1 | Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-28 | — | — | EP | disclosed |