Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13102339 | 0.98 | MAPT (0.57) | MAPTKMT2AMEN1HRH3NPSR1 | |
| SCHEMBL14924426 | 0.86 | MAPT (0.55) | MAPTNPSR1ADRA2AADRA2BADRA2C | |
| SCHEMBL1844995 | 0.83 | NPC1 (0.50) | KMT2AHRH3ADRA2AADRA2BADRA2C | |
| SCHEMBL13841388 | 0.83 | TSHR (0.60) | MAPTKMT2AMEN1POLBKDM4E | |
| SCHEMBL14466590 | 0.83 | MAPT (0.52) | MAPTKMT2AMEN1HRH3NPSR1 | |
| SCHEMBL23671492 | 0.82 | SIGMAR1 (0.56) | ADRA2AADRA2BADRA2CKDM4EALDH1A1 | |
| SCHEMBL4804050 | 0.82 | ALDH1A1 (0.50) | MAPTKMT2AMEN1HRH3NPSR1 | |
| SCHEMBL10891769 | 0.82 | CNR1 (0.59) | KMT2AMEN1HRH3POLBKDM4E | |
| SCHEMBL8673780 | 0.81 | POLB (0.59) | MAPTKMT2AMEN1HRH3NPSR1 | |
| Hydrochloric Acid SCHEMBL11758276 | 0.80 | MAPT (0.58) | MAPTKMT2AMEN1HRH3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384952-B2 | Pyrazolopyrimidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-06-10 | — | — | US | disclosed |
| US-7384952-B2 | Pyrazolopyrimidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-06-10 | — | — | US | disclosed |
| EP-1857459-A2 | Pyrazolopyrimidine compound and a process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 2007-11-21 | — | — | EP | disclosed |