Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2259440 | 0.93 | TGFBR1 (0.44) | MAPTPOLBTGFBR1KDM4EHPGD | |
| SCHEMBL15707237 | 0.92 | ALDH1A1 (0.43) | MAPTPOLBTGFBR1TP53HPGD | |
| SCHEMBL2257831 | 0.91 | TGFBR1 (0.42) | MAPTMAPK1TGFBR1KDM4EHPGD | |
| SCHEMBL2262678 | 0.91 | RAB9A (0.46) | MAPTPOLBTGFBR1TP53KDM4E | |
| SCHEMBL2255675 | 0.91 | STAT3 (0.56) | GAAMAPTHTTPOLBMAPK1 | |
| SCHEMBL14177233 | 0.90 | KMT2A (0.47) | GAAMAPTPOLBSTAT3TGFBR1 | |
| SCHEMBL2254861 | 0.90 | TRPM4 (0.46) | MAPTTGFBR1KDM4EHPGDP2RY1 | |
| SCHEMBL2259796 | 0.90 | TP53 (0.47) | MAPTPOLBTP53KDM4EHPGD | |
| SCHEMBL2259083 | 0.89 | RXRA (0.44) | POLBSTAT3TGFBR1KDM4EHPGD | |
| SCHEMBL2257923 | 0.89 | HPGD (0.47) | GAAMAPTPOLBTGFBR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |