Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466379 | 0.87 | P2RX7 (0.34) | TOP2ATOP2BALDH1A1KDM4ELMNA | |
| SCHEMBL140764 | 0.85 | KCNH2 (0.37) | ALDH1A1KDM4EHPGDHSD17B10KCNH2 | |
| SCHEMBL143726 | 0.85 | TOP2A (0.39) | TOP2ATOP2BALDH1A1KDM4ELMNA | |
| SCHEMBL141441 | 0.80 | KCNH2 (0.31) | KCNH2 | |
| SCHEMBL3134076 | 0.78 | KCNH2 (0.38) | TOP2ATOP2BALDH1A1KDM4ELMNA | |
| SCHEMBL143606 | 0.78 | KCNH2 (0.40) | TOP2ATOP2BALDH1A1KDM4ELMNA | |
| SCHEMBL6218399 | 0.77 | KCNH2 (0.38) | ALDH1A1KDM4EMAPTHPGDKCNH2 | |
| SCHEMBL29023850 | 0.77 | KDM4E (0.41) | TOP2ATOP2BALDH1A1KDM4ELMNA | |
| SCHEMBL7576971 | 0.76 | KCNH2 (0.37) | MAPTKCNH2GSK3BMEN1KMT2A | |
| SCHEMBL142409 | 0.76 | GSK3B (0.37) | TOP2ATOP2BALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | RECQL, BLVRB, NQO2 | TOP2A 125/4885TOP2B 31/4885ALDH1A1 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.